Spicy Cajun Chicken Alfredo

Featured in: Weeknight Dinners

This stunning dish combines tender Cajun-seasoned chicken with a velvety Alfredo sauce made from butter, garlic, heavy cream, and Parmesan cheese. The chicken is pan-seared until golden, then sliced and tossed with perfectly cooked pasta and the luxurious sauce. Fresh parsley and extra Parmesan finish this unforgettable meal that brings Southern spice to classic Italian comfort food.

Updated on Sun, 18 Jan 2026 08:43:00 GMT
Creamy Cajun Chicken Alfredo with tender chicken strips and fettuccine, garnished with fresh parsley and Parmesan. Pin it
Creamy Cajun Chicken Alfredo with tender chicken strips and fettuccine, garnished with fresh parsley and Parmesan. | purposepan.com

The first bite of Cajun Chicken Alfredo happened on a Tuesday night when I had leftover Cajun seasoning and a craving for something creamy. I tossed seasoned chicken into a hot skillet, and the smell that filled my kitchen was so good my neighbor texted asking what I was cooking. By the time I stirred the Parmesan into the cream, I knew this wasn't just dinner, it was going to be one of those recipes I'd make again and again. The balance of spice and richness felt like comfort food with a kick, and I've been hooked ever since.

I made this for a small dinner party once, and my friend who claimed she didn't like spicy food went back for seconds. She said the cream mellowed the heat just enough to make it exciting instead of overwhelming. That night taught me that this dish has a way of winning people over, even the skeptics. It's become my go to when I want to impress without spending all day in the kitchen.

Ingredients

  • Boneless, skinless chicken breasts: These cook quickly and soak up the Cajun seasoning beautifully, but make sure to pat them dry first so the spices stick and the sear is golden.
  • Cajun seasoning: This is where the magic happens, bringing paprika, garlic, cayenne, and herbs all in one spice blend that transforms plain chicken into something bold.
  • Olive oil: A high smoke point oil is key here since you're searing the chicken over medium high heat, and olive oil adds a subtle richness.
  • Fettuccine or linguine: Wide, flat noodles hold onto the creamy sauce better than thinner pasta, and they give each bite that perfect sauce to noodle ratio.
  • Unsalted butter: This is the base of your Alfredo, and using unsalted lets you control the salt level since Parmesan is already salty.
  • Garlic: Fresh minced garlic blooms in the butter and perfumes the entire sauce, so don't skip this or use the jarred stuff.
  • Heavy cream: The backbone of Alfredo, it thickens beautifully when simmered and gives the sauce that luxurious, silky texture.
  • Parmesan cheese: Freshly grated is non negotiable, the pre shredded kind has anti caking agents that make the sauce grainy instead of smooth.
  • Black pepper and salt: Simple seasonings that let the Parmesan and Cajun spice shine without competing.
  • Red pepper flakes: Optional, but if you like a little extra heat lingering on your tongue, toss these in.
  • Fresh parsley: A bright, herby finish that cuts through the richness and makes the plate look as good as it tastes.

Instructions

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Cook the pasta:
Bring a big pot of salted water to a rolling boil and drop in your fettuccine, cooking it until it's just tender with a slight bite. Before you drain, scoop out half a cup of that starchy pasta water, it's your secret weapon for adjusting the sauce later.
Prepare the chicken:
Pat those chicken breasts completely dry with paper towels, then rub the Cajun seasoning all over, pressing it in so it sticks. This step makes all the difference in getting a flavorful, crispy exterior.
Sear the chicken:
Heat the olive oil in a large skillet over medium high until it shimmers, then lay the chicken in and let it cook undisturbed for 5 to 6 minutes per side until golden and cooked through. Let it rest a few minutes before slicing so the juices stay inside.
Make the Alfredo sauce:
In the same skillet, melt butter over medium heat and toss in the garlic, stirring for about 30 seconds until it smells incredible. Pour in the heavy cream, whisking as it heats, and bring it to a gentle simmer without letting it boil.
Thicken the sauce:
Stir in the Parmesan, black pepper, salt, and red pepper flakes if using, and let it simmer for 2 to 3 minutes until it coats the back of a spoon. If it gets too thick, splash in some of that reserved pasta water a tablespoon at a time.
Combine everything:
Add the cooked pasta to the skillet and toss it around until every strand is coated in that creamy, cheesy sauce. Lay the sliced Cajun chicken on top and toss once more to bring it all together.
Serve hot:
Plate it up right away, sprinkle with fresh parsley and extra Parmesan, and enjoy it while the sauce is still clinging to the noodles.
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Spicy Cajun Chicken Alfredo served hot with golden-seared chicken and rich, velvety Alfredo sauce over pasta. Pin it
Spicy Cajun Chicken Alfredo served hot with golden-seared chicken and rich, velvety Alfredo sauce over pasta. | purposepan.com

One evening, I served this to my dad who's a meat and potatoes kind of guy, and he scraped his plate clean without saying a word. When he finally looked up, he just nodded and said, make this again. That quiet approval meant more than any compliment, and now this dish is on rotation whenever he visits.

How to Customize Your Cajun Alfredo

This recipe is forgiving and loves a little creativity. I've stirred in sautéed bell peppers for sweetness and crunch, and I've swapped chicken for shrimp when I'm in a seafood mood. If you want to sneak in some greens, a handful of spinach wilts beautifully into the hot sauce. You can also dial the heat up or down by adjusting the Cajun seasoning or adding more red pepper flakes.

Pairing and Serving Suggestions

This dish is rich, so I like to serve it with something light and crisp on the side. A simple arugula salad with lemon vinaigrette cuts through the cream, and garlic bread is always a crowd pleaser for soaking up extra sauce. A chilled glass of Sauvignon Blanc or even a sparkling water with lime keeps the palate refreshed between bites.

Storage and Reheating Tips

Leftovers keep well in an airtight container in the fridge for up to three days, and I've found the flavors deepen overnight. When reheating, add a splash of cream or milk to the pan over low heat and stir gently until it loosens up. The microwave works in a pinch, but stovetop reheating brings back that silky texture.

  • Store the chicken and pasta together, the sauce keeps everything moist.
  • Reheat gently to avoid breaking the cream sauce.
  • Add a sprinkle of fresh Parmesan after reheating for a just made taste.
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A close-up of Cajun Chicken Alfredo, showcasing saucy fettuccine, seasoned chicken, and a sprinkle of red pepper flakes. Pin it
A close-up of Cajun Chicken Alfredo, showcasing saucy fettuccine, seasoned chicken, and a sprinkle of red pepper flakes. | purposepan.com

This Cajun Chicken Alfredo has earned its place in my weekly rotation, and I hope it does the same in yours. It's the kind of dish that feels like a treat but doesn't demand hours of your time, and that balance is what keeps me coming back.

Recipe FAQs

How do I prevent the Alfredo sauce from breaking?

Keep the heat at medium and whisk constantly when adding the cream. Avoid boiling, which can cause the sauce to separate. If it becomes too thick, thin it gradually with reserved pasta water rather than adding more liquid at once.

Can I make this dish ahead of time?

Prepare the chicken and sauce separately up to a few hours in advance. Store in the refrigerator. Reheat gently on the stovetop with a splash of cream or pasta water, then combine with freshly cooked pasta for best texture and flavor.

What's the best way to cook chicken breasts evenly?

Pound the breasts to uniform thickness before seasoning and cooking. This ensures they cook through at the same rate. Use a meat thermometer to verify doneness at 165°F internal temperature for food safety.

How can I adjust the heat level?

Control spiciness by modifying the amount of Cajun seasoning on the chicken. Add red pepper flakes to the sauce for additional heat, or omit them entirely for a milder version. Taste as you go and adjust to your preference.

What substitutions work for this dish?

Replace chicken with large shrimp or tofu for different proteins. Swap fettuccine for penne or linguine. Add sautéed vegetables like bell peppers, spinach, or mushrooms to the sauce for extra flavor and nutrition.

Which wine pairs well with this meal?

Crisp white wines like Sauvignon Blanc or Pinot Grigio complement the creamy sauce and spicy chicken beautifully. The acidity cuts through the richness while the subtle fruit notes enhance the Cajun flavors.

Spicy Cajun Chicken Alfredo

Cajun-spiced chicken breast paired with creamy Alfredo sauce and fettuccine pasta. A bold fusion dish ready in under an hour.

Prep time
15 minutes
Cook time
25 minutes
Total duration
40 minutes
Author Amelia Cook


Skill Level Medium

Cuisine American Cajun-Italian Fusion

Portions 4 Serving size

Diet Information None specified

What You Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 1/2 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/4 teaspoon ground black pepper
06 1/4 teaspoon salt
07 1/4 teaspoon red pepper flakes

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese for serving

Step-by-Step Guide

Step 01

Cook the pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package directions until al dente. Reserve 1/2 cup pasta water and drain remaining water. Set pasta aside.

Step 02

Prepare the chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on all sides.

Step 03

Cook the chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken breasts and cook 5 to 6 minutes per side until golden and cooked through, reaching internal temperature of 165°F. Remove from skillet, rest for 2 to 3 minutes, then slice into strips.

Step 04

Create the Alfredo sauce: In the same skillet over medium heat, melt butter. Add minced garlic and sauté for 30 seconds until fragrant. Pour in heavy cream, whisking constantly, and bring to a gentle simmer without boiling.

Step 05

Season and thicken the sauce: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes. Simmer for 2 to 3 minutes until sauce reaches desired thickness. Add reserved pasta water one tablespoon at a time if sauce becomes too thick.

Step 06

Combine ingredients: Add cooked pasta to the skillet and toss thoroughly to coat with Alfredo sauce. Add sliced Cajun chicken and toss again until evenly distributed.

Step 07

Plate and serve: Transfer to serving plates immediately and garnish with chopped fresh parsley and extra grated Parmesan cheese.

What You'll Need

  • Large pot for boiling pasta
  • Large skillet for cooking chicken and sauce
  • Tongs for handling chicken
  • Chef's knife for slicing and mincing
  • Cutting board for knife work
  • Measuring cups and spoons for accurate portioning
  • Whisk for sauce preparation

Allergy List

Review all items for allergens and talk to a medical expert if you're unsure.
  • Contains milk: heavy cream, butter, Parmesan cheese
  • Contains wheat: pasta
  • May contain eggs if using fresh pasta varieties
  • Verify Cajun seasoning ingredients for gluten and cross-contamination risks if sensitivity exists

Nutrition details (per portion)

Nutrition details are just for your reference and shouldn't substitute a medical consultation.
  • Calories: 670
  • Fat content: 34 grams
  • Carbohydrates: 54 grams
  • Protein: 40 grams